Handbook of Analytical Derivatization Reactions

Author: Daniel R. Knapp
Published by: John Wiley & Sons
ISBN: 0-471-03469-X

Much of the analytical work involving GC and GC/MS involves the use of analytical derivatization prior to analysis. Analytical deriva-tization reactions find application in virtually any area of work in-volving analysis of organic compounds.

Particularly the analysis of polar compounds, albeit in biological samples or any other type of (aqueous) sample, has greatly bene-fited from analytical derivatization. Without it, these compounds would not be amenable to GC or GC/MS analysis at all!


The Handbook of Chemical Derivatization Reactions provides a detailed and concise overview of possible derivatization reactions as function of compound chemistry and functionality, much alike an encyclopedia or a compendium.

Particularly the extent of derivatization reactions and target compounds is staggering. The analysis of carboxylic acids, for example, is dealt with in no less than 70 pages covering all kinds of deriva-tives and reagents. As such, the Handbook is an invaluable tool voor everyone who regularly comes across challenging analytical problems that could be resolved with derivatization. Just take a quick look in the Handbook to verify the possibilities and choose the one that suits best.

It is clear that the Handbook of Chemical Derivatisation Reactions is invaluable for everyone who is working in biomedical, clinical, forensic, environmental, etc chemistry. We have been using the Handbook for many years with great success, you too?

Reviewed by Joeri Vercammen
Manager